DORI brings together a diverse group of researchers spanning over 26 divisions & departments across the University of Southern California.
All of Us Research Program
The All of Us Research Program has a simple mission. We want to speed up health research breakthroughs. To do this, we’re asking one million people to share health information. In the future, researchers can use this to conduct thousands of health studies. Participants must be 18 years of age and over.
This study looks at the risks for diabetes and obesity in children whose mothers had diabetes during pregnancy. We hope to learn about how being exposed to diabetes in utero may affect risk for diabetes and obesity in children. In particular, we are interested in examining behavior and brain development in children whose mothers had gestational diabetes mellitus (GDM).
Brain Response to Sugar
This study is about how the brain responds to different types of sugars. Particularly, how the brain responds to glucose, fructose, and sucrose, and how this response may be different in young people who are overweight and obese compared to those who are normal weight.
Genetics of Liver Fat (GoLF) Study
The Genetics of Liver Fat (GoLF) Study is examining how differences in genes (the “blue print” for all inherited traits) may determine why some people are more likely to develop fat in their liver and how that fat level contributes to the risk for type 2 diabetes.
Mitochondrial Derived Peptides Research
The Cohen lab investigates the role that mitochondrial derived peptides play in obesity and diabetes and their possible use as novel therapeutics.
Mothers' and Their Children's Health Study (MATCH)
The MATCH Study examines how maternal stress may compromise parenting practices related to their children’s dietary and physical activity, and contribute to obesity risk over time.
Phone: (323) 442-8224
Sedentary Behavior and Health Outcomes Study
This groundbreaking study will examine whether past energy balance behaviors predict the metabolic response to interrupting sitting time in healthy children. We will also study the effects of the social context and home environment on these energy balance behaviors and glucose homeostasis using ecological momentary assessment and continuous glucose monitoring.
This study will inform future targeted intervention strategies to prevention or ameliorate the consequences of childhood obesity and type 2 diabetes.
For more information, please email us at firstname.lastname@example.org
The TIME Study uses smartphones and smartwatches to collect intensive longitudinal data to examine how psychological and contextual factors affect the adoption and maintenance of physical activity, sedentary, and sleep behaviors across 12 months in young adults.
Phone: (323) 442-8224
Specific Research Areas of Interest
To facilitate collaboration and guide the development of the Institute, the DORI developed an initial seven research categories, to provide a forum for topical discussion and the development of collaborative pilot studies.
These are by no means research “silos”, rather broad topics to be researched and attacked from diverse perspectives.
Researchers meet individually and through periodic Institute retreats that offer opportunities for collaboration, learning, and pilot study funding. As the Institute develops, additional research areas will be developed.
How you can support us
Your donation supports scientists, funds cutting edge research, and the training and education of students and young researchers. Any donation amount can provide seed funding in order to obtain NIH funding, bridge NIH funding gaps, or recruit world-class faculty.
Cardiometabolic disorders such as obesity and diabetes are key modifiable risk factors for Alzheimer’sdisease and related dementias (ADRD). These disorders contribute to the development and progression ofADRD by promoting brain
Job postings for Research Director for the Endocrinology Division at Children’s Hospital Los Angeles
(PhD) https://usccareers.usc.edu/job/los-angeles/associate-professor-of-pediatrics-tenure-chla/1209/52066187936 (MD/DO) https://usccareers.usc.edu/job/los-angeles/associate-or-professor-of-clinical-pediatrics-divison-of-endocrinology-chla/1209/51932515504
Understanding the role of binge eating in obesity and the underlying momentary cognitive and affective mechanisms – Tuesday, May 23, 2023 at 12 pm- Kathryn Smith, PhD
Understanding the role of binge eating in obesity and the underlying momentary cognitive and affective mechanisms This grand rounds will provide an overview of the significance of binge eating
https://usc.zoom.us/rec/share/OTqOcEagKVqvbIOIRjRU_W0GjesWKYcoWiZ2f2pxZdLJ4A1YTnSoVE_chL5rSJvy.puh0kAEHKNY5SLeL Passcode: z4fazf!3
Role of Gut Bacteria in Cardiovascular and Metabolic Risks Due to High Na+ and Low K+ Diet High-sodium and low-potassium (HNaLK) content in Western diets increases the risks of cardiovascular
Below is the symposium recording for everyone to view: https://keckmedia.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=632d6e1e-1835-4582-b69b-afb70119cccd
Happy New Year’s! Please join us for USC’s DORI Seminar on Friday, January 27, 2023 at 12 pm in-person at UPC. Warm and Full: Neural Circuits for Behavioral Regulation of
Tuesday, April 12, 2022 – 8:30 AM to 5:45 PM
March 2022 Shared DORI Webinar & Endocrinology Grand Rounds- Alan Watts, D. Phil (meeting recording)
Topic: Glucosensory Networks in the Brain: Functional Implications for Glycemic Counterregulation Meeting Recording: https://usc.zoom.us/rec/share/9OKcecDkO0QG_lOf5DUFR2lBWyQUOk6u7C4v3eIXI314Qq_r8WMgb8xKgRvrFLrr.S2WbSYH6Lfww699Q Access Passcode: 6.@Qv=*f
FY22 DORI Request for Pilot Funding:Establishing New Collaborative Research TeamsThe USC Diabetes & Obesity Research Institute (DORI) is pleased to announce a call for new pilot award proposals. Awards will
Glucosensory Networks in the Brain: Functional Implications for Glycemic Counterregulation Date: March 15, 2022 (Tuesday) Time: 12:00PM-1:00PM Zoom registration link: https://usc.zoom.us/webinar/register/WN_QMfiD70HSVKfMjSmMfA0Pw Eligible for 1 CME if watched live.See additional CME
EVENT: USC DORI’s 9th Annual Research Symposium on Diabetes & Obesity DATE: Tuesday, April 12, 2022 TIME: 8:30 AM to 5:45 PM LOCATION: USC Health Science Conference Center Hyatt House
January 2022 Shared DORI Webinar & Endocrinology Grand Rounds- Camilla Ferreira Wenceslau, PhD (Meeting recording)
Topic: Microbiota are Critical for Vascular Physiology https://usc.zoom.us/rec/share/cLTZrMuI7MKtNSB2oVmir3YIt6nwEWzoWl-zFkkePH0I3QzMxGCFZEUlccxOxdRv.x4_igXiYXcY7K72m Passcode: 21hUMn!.
DATE: January 18, 2022 (Tuesday) TIME: 12:00-1:00 PM Zoom Registration Link:https://usc.zoom.us/webinar/register/WN_0UX01q-pTy-FVrQa4AWxXg 1 CME will be offered if watched live.See additional CME attachments.
Meeting Recording: https://usc.zoom.us/rec/share/c64YlUvCRDpq6FF-2CbJkojnRY-78om7aRqVFWtXiOwOeCGTSGZi43Hq-W_u7Ar4.8R2_CAsVeHoIWX_k Access Passcode: .ea7rV55
The National Institute of Diabetes, Digestive and Kidney Diseases Intramural Research Program (NIDDK IRP), part of the National Institutes of Health, announces the Distinguished Postbaccalaureate Scholars Program for recent college
DATE: December 14, 2021 TIME: 12:00-1:00 PM Zoom Registration Link:https://usc.zoom.us/webinar/register/WN_JrdJt0apTdGiU1LToIDQrw 1 CME will be offered if watched live.See CME additional attachments.
Shared DORI Webinar/Grand Rounds with the Department of Endocrinology: Michael Goran, PhD (Seminar Recording) November 9, 2021
Topic: Shared DORI Webinar/Grand Rounds with the Department of Endocrinology: Michael Goran, PhD Date: Nov 9, 2021 Passcode: F%Ye@.4G https://usc.zoom.us/rec/share/0uZVzizNsCdhPNZH_L9u6MydrgR4YHGugRgo5PyHLGrLz_CMqssXc_wVq91Yacl1.59vw_VDJMzq10Bsw
DATE: November 9, 2021 TIME: 12:00-1:00 PM Michael Goran PhD Zoom Registration Link:https://usc.zoom.us/webinar/register/WN_6fi-EJOnR5u-WGO5p4sUiA 1 CME will be offered if watched live.CME Credit This session will be recorded.
October 2021 Shared DORI Webinar & Endocrinology Grand Rounds- Senta Georgia, PhD (Meeting Recording)
Meeting Recording: https://usc.zoom.us/rec/share/T5AfBWpF-efmIbi7_ERjzUPtHQ18U864jwklNDVsbn_GjwAP4IUMV6j6kw9ysXM6.c5POzmnKsA58HLla Access Passcode: 4^pY1N5y
We Are Accepting Abstracts for Oral and PosterPresentations from Students, Fellows, Postdocs, and Staff Postponed. Will post new date and information soon.
Postponed. Will post new date and information soon. Aresty Auditorium and NRT LG 503/504Norris Research TowerKeck School of Medicine of USC1450 Biggy StreetLos Angeles, CA 90033
Zoom Registration Link:https://usc.zoom.us/webinar/register/WN_SeIERW_lQ_W0H5aXj1smqA
Link to the recording of April 13, 2021 presentations: Meeting Recording:https://usc.zoom.us/rec/share/q8xQR6TlsgzcgmJdBBbYNi270LCldQZi_zprwpQdfpa5zmaXAq8Bssszzic516Y.wvb2Biu3BViJD929 Access Passcode: $0JuaNXN
DORI’s symposium on March 9, 2021 was recorded and can be viewed at the following zoom link.
DORI’s symposium on February 9, 2021 was recorded and can be viewed at the following zoom link.
Impact of Gastric Banding Versus Metformin on β-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes
Publication by Anny H. Xiang, Enrique Trigo, Mayra Martinez, Namir Katkhouda, Elizabeth Beale, Xinhui Wang, Jun Wu,Ting Chow, Cortney Montgomery, Krishna S. Nayak, Fadi Hendee, Thomas A. Buchanan and for the RISE Consortium in the following link:
Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis
Publication by Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret. Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype.
Publication by Mitchell JA, Chesi A, McCormack SE, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SFA, Zemel BS. This study aimed to determine if replacing time spent in high- and low-impact physical activity (PA) predicts changes in pediatric bone mineral density (BMD) and content (BMC).
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.
Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index.
In this study, we examined whether exposure to elevated concentrations of NRAP during in utero and/or first year of life increase childhood BMI growth. ublication by Kim JS, Alderete TL, Chen Z, Lurmann F, Rappaport E, Habre R, Berhane K, Gilliland FD.
Menstrual Dysfunction in Girls From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.
Context: Little is known about reproductive function in girls with youth-onset type 2 diabetes.
Objectives: To characterize girls with irregular menses and effects of glycemic treatments on menses and sex steroids in the Treatment Options for Type 2 Diabetes in Youth (TODAY) study. Publication by Kelsey MM, Braffett BH, Geffner ME, Levitsky LL, Caprio S, McKay SV, Shah R, Sprague JE, Arslanian SA; TODAY Study Group.
A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.
Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. Publication by Bochukova EG, Lawler K, Croizier S, Keogh JM, Patel N, Strohbehn G, Lo KK, Humphrey J, Hokken-Koelega A, Damen L, Donze S, Bouret SG, Plagnol V, Farooqi IS.
Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents.
The primary aim of this study was to determine whether elevated TRAP exposure was correlated with gut bacterial taxa in overweight and obese adolescents from the Meta-AIR (Metabolic and Asthma Incidence Research) study. Publication by Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI.
Acculturation to the US culture is associated with suboptimal dietary choices in Latino youth. The role of parental education in shaping children’s nutrition is less clear. The purpose of this study was to examine the relationships between parental education, acculturation and dietary intake in 96 Latino youth ages 8-18 years. Publication by Hasson RE, Hsu YJ, Davis JN, Goran MI, Spruijt-Metz D.
High-Fructose Corn-Syrup-Sweetened Beverage Intake Increases 5-Hour Breast Milk Fructose Concentrations in Lactating Women.
This study determined the effects of consuming a high-fructose corn syrup (HFCS)-sweetened beverage on breast milk fructose, glucose, and lactose concentrations in lactating women. Publication by Berger PK, Fields DA, Demerath EW, Fujiwara H, Goran MI.
Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.
Our findings identify a novel crosstalk between macrophages and skeletal muscle in the modulation of obesity-mediated insulin resistance. Publication by Kim JH, Lee E, Friedline RH, Suk S, Jung DY, Dagdeviren S, Hu X, Inashima K, Noh HL, Kwon JY, Nambu A, Huh JR, Han MS, Davis RJ, Lee AS, Lee KW, Kim JK.
The goal of this paper is to review the diagnosis and management of Graves’ hyperthyroidism in pregnancy. The paper will discuss preconception counseling, etiologies of hyperthyroidism, thyroid function testing, pregnancy-related complications, maternal management, including thyroid storm, anti-thyroid drugs and the complications for mother and fetus, fetal and neonatal thyroid function, neonatal management, and maternal post-partum management. Publication by Nguyen CT, Sasso EB, Barton L, Mestman JH.
Effects of Physical Activity and Sedentary Behavior on Brain Response to High-Calorie Food Cues in Young Adults.
Physical activity may have beneficial effects on brain regulation of feeding behavior after caloric intake in lean individuals and individuals with obesity. Publication by Luo S, O’Connor SG, Belcher BR, Page KA.
Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.
The Restoring Insulin Secretion (RISE) study was initiated to evaluate interventions to slow or reverse the progression of β-cell failure in type 2 diabetes (T2D). Publication by Hannon TS, Kahn SE, Utzschneider KM, Buchanan TA, Nadeau KJ, Zeitler PS, Ehrmann DA, Arslanian SA, Caprio S, Edelstein SL, Savage PJ, Mather KJ; RISE Consortium.
Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial.
Purpose Metabolic syndrome is associated with an increased risk of cardiovascular disease, type 2 diabetes, and breast cancer recurrence in survivors of breast cancer. Publication by Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Buchanan TA, Spicer DV, Tripathy D, Bernstein L, Mortimer JE.
Use of oral agents to treat gestational diabetes mellitus remains controversial. Recent recommendations from the Society for Maternal-Fetal Medicine assert that metformin may be a safe first-line alternative to insulin for gestational diabetes mellitus treatment and preferable to glyburide. Publication by Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW Jr, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR.
Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop on research gaps in gestational diabetes mellitus (GDM) with a focus on 1) early pregnancy diagnosis and treatment and 2) pharmacologic treatment strategies. Publication by Wexler DJ, Powe CE, Barbour LA, Buchanan T, Coustan DR, Corcoy R, Damm P, Dunne F, Feig DS, Ferrara A, Harper LM, Landon MB, Meltzer SJ, Metzger BE, Roeder H, Rowan JA, Sacks DA, Simmons D, Umans JG, Catalano PM
Clinical Endocrinology News highlighted a study by Thomas Buchanan, MD, professor of medicine, comparing gastric banding and metformin for improving insulin sensitivity in patients with early Type 2 diabetes.
Occupational Therapy Intervention Improves Glycemic Control and Quality of Life Among Young Adults With Diabetes: the Resilient, Empowered, Active Living with Diabetes (REAL Diabetes) Randomized Controlled Trial.
To assess the efficacy of a manualized occupational therapy (OT) intervention (Resilient, Empowered, Active Living with Diabetes [REAL Diabetes]) to improve glycemic control and psychosocial well-being among ethnically diverse young adults with low socioeconomic status (SES) who have type 1 or type 2 diabetes. Publication by Pyatak EA, Carandang K, Vigen CLP, Blanchard J, Diaz J, Concha-Chavez A, Sequeira PA, Wood JR, Whittemore R, Spruijt-Metz D, Peters AL.
Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study.
Evaluate the efficacy and safety of the dual sodium-glucose cotransporter 1 (SGLT1) and SGLT2 inhibitor sotagliflozin in combination with optimized insulin in type 1 diabetes (T1D). Publication by Buse JB, Garg SK, Rosenstock J, Bailey TS, Banks P, Bode BW, Danne T, Kushner JA, Lane WS, Lapuerta P, McGuire DK, Peters AL, Reed J, Sawhney S, Strumph P.
HbA1c and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study.
he objective of this study was to evaluate the efficacy and safety of the dual sodium-glucose cotransporter 1 and 2 inhibitor sotagliflozin compared with placebo when combined with optimized insulin in adults with type 1 diabetes (T1D). Publication by Danne T, Cariou B, Banks P, Brandle M, Brath H, Franek E, Kushner JA, Lapuerta P, McGuire DK, Peters AL, Sawhney S, Strumph P.
T1-REDEEM: A Randomized Controlled Trial to Reduce Diabetes Distress Among Adults With Type 1 Diabetes
To compare the effectiveness of two interventions to reduce diabetes distress (DD) and improve glycemic control among adults with type 1 diabetes (T1D). Publication by Fisher L, Hessler D, Polonsky WH, Masharani U, Guzman S, Bowyer V, Strycker L, Ahmann A, Basina M, Blumer I, Chloe C, Kim S, Peters AL, Shumway M, Weihs K, Wu P.
Improved Postprandial Glucose with Inhaled Technosphere Insulin Compared with Insulin Aspart in Patients with Type 1 Diabetes on Multiple Daily Injections: The STAT Study.
he primary purpose of this study was to assess both glucose time-in-range (TIR: 70-180 mg/dL) and postprandial glucose excursions (PPGE) in 1-4 h using a real-time continuous glucose monitor (CGM) with Technosphere insulin (TI) versus insulin aspart in patients with type 1 diabetes (T1DM) on multiple daily injections (MDI). Publication by Akturk HK, Snell-Bergeon JK, Rewers A, Klaff LJ, Bode BW, Peters AL, Bailey TS, Garg SK.
This study investigates brain metabolism and function in a liver-specific Phosphatase and Tensin Homologue (Pten) knockout mouse model (Liver-PtenKO), a negative regulator of insulin signaling. Publication by Patil I, Sancheti H, Stiles BL, Cadenas E.
The goal is to review current methodologies used to analyze disease-related quantitative traits for those who do not have extensive quantitative and physiologic background, as an attempt to bridge that gap. ublication by Watanabe RM.
Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans.
Limited studies have assessed the relationship between longitudinal changes in adiposity and changes in multiple adipokines over time. This study examined changes in BMI, total body fat, and trunk fat associated with changes in 16 circulating adipokines in Mexican Americans at risk for type 2 diabetes. Publication by Black MH, Shu YH, Wu J, Koebnick C, MacKay A, Watanabe RM, Buchanan TA, Xiang AH.
Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS).
In the Insulin Resistance Atherosclerosis Family Study (IRASFS), heritability estimates suggest a strong genetic basis: low-density lipoprotein (LDL, h2 = 0.50), high-density lipoprotein (HDL, h2 = 0.57), total cholesterol (TC, h2 = 0.53), and triglyceride (TG, h2 = 0.42) levels. Publication by Gao C, Tabb KL, Dimitrov LM, Taylor KD, Wang N, Guo X, Long J, Rotter JI, Watanabe RM, Curran JE, Blangero J, Langefeld CD, Bowden DW, Palmer ND.
Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans.
This report assessed three adiposity measures (BMI, percent body fat, trunk fat), insulin resistance, and fifteen adipokines in relationship to longitudinal change in β-cell function measured by disposition index (DI) from frequently-sampled-intravenous-glucose-tolerance testing. Publication by Xiang AH, Black MH, Shu YH, Wu J, MacKay A, Koebnick C, Watanabe RM, Buchanan TA.
Protocol for the Imagine HEALTH Study: Guided imagery lifestyle intervention to improve obesity-related behaviors and salivary cortisol patterns in predominantly Latino adolescents.
nnovative lifestyle interventions are needed to reduce type 2 diabetes risk in adolescents. This report describes the protocol of the Imagine HEALTH cluster randomized control trial, that tests an intervention based in Self-Determination Theory (SDT) and uses lifestyle education combined with the mind-body, complementary health modality of guided imagery (GI), to address obesity prevention and treatment in predominantly Latino adolescents. Publication by Weigensberg MJ, Spruijt-Metz D, Wen CKF, Davis JN, Ávila Q, Juarez M, Brown-Wadé N, Lane CJ.
The All of Us Research Program has a simple mission. We want to speed up health research breakthroughs. To do this, we’re asking one million people to share health information.
DORI researcher, Senta Georgia, PhD has been selected for an oral abstract presentation at the ADA’s 78th Conference
DORI researcher, Senta Georgia, PhD has been selected for an oral abstract presentation at the American Diabetes Association’s 78th Scientific Sessions, June 22-26, 2018 in Orlando, Florida. Her abstract, “CRISPR-Cas9 Gene Editing Restores Beta-Cell Differentiation and Function in Patient-Specific iPSC’s,” will be printed in the Scientific Sessions’ Abstract Book, the July 2018 supplement to the journal Diabetes.
DORI researcher, Joyce Richey, PhD, has published in Current Diabetes Reports: “Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases”
DORI researcher, Senta Georgia, PhD, has published in Current Diabetes Reports: “Gene Editing and Human Pluripotent Stem Cells: Tools for Advancing Diabetes Disease Modeling and Beta-Cell Development”
USC DORI is hosting a no-cost 2-day symposium on February 27 & 28, 2018.
February 27th will begin at 11:00am with 5 speakers and student/postdoc/fellow oral and poster presentations. February 28th will begin at 8:30am with 7 speakers and student/postdoc/fellow oral and poster presentations.
USC researchers have identified a gene variant that decreases the risk of heart disease — but only among women. Men who carry the variant receive no protective effect.
Hooman Allayee, senior author of the study and associate professor of preventive medicine at the Keck School of Medicine of USC, said scientists have long known that heart disease affects men and women differently, but what causes the difference has not been entirely clear. This new finding may shed light on that mystery.
DORI researcher, Katie Page, MD, has published a new study in PNAS “Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food
New study offers hope of future treatments to help prevent weight problems
Researchers at The Saban Research Institute of Children’s Hospital Los Angeles reveal an unexpected role for ghrelin in early brain development and show its long-term impact on appetite regulation. Their study was published online on January 20 by The Journal of Clinical Investigation.
Sugar consumption led to memory problems and brain inflammation. Studying rats as model subjects, scientists found that adolescents were at an increased risk of suffering negative health effects from sugar-sweetened beverage consumption.
Congratulations to Fred Sattler, Steve Mittelman, and Ralf Langen & Pinchas Cohen for winning the DORI’s 2nd pilot proposal submission! Fred is from the Department of Medicine and his proposal is entitled
Drs. Casey Donovan and Alan Watts’ work on two published papers addressing glucosensing mechanisms in the hepatic portal vein and the brain as they relate to insulin-induced hypoglycemia and counterregulatory responses. They believe this work may help improve our understanding of the actions of insulin therapy, particularly in patients with type 1 diabetes.
Activation of Hindbrain Neurons Is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia
MaryAnn Bohland, Aleksey V. Matveyenko, Maziyar Saberi, Arshad M. Khan, Alan G. Watts, and Casey M. Donovan Hypoglycemic detection at the portal-mesenteric vein (PMV) appears mediated by spinal afferents and
The Rate of Fall of Blood Glucose Determines The Necessity of Forebrain-Projecting Catecholaminergic Neurons for Male Rat Sympathoadrenal Responses
Anne J. Jokiaho, Casey M. Donovan and Alan G. Watts Different onset rates of insulin-induced hypoglycemia use distinct glucosensors to activate sympathoadrenal counterregulatory responses (CCRs). Glucosensory elements in the portal-mesenteric
DORI’s First Annual Research Symposium From Cells to Psychology: Integrative Insights into Diabetes & Obesity Wednesday, February 19, 2014 from 8am to 5pm Keck School of Medicine of USC Norris
Congratulations to Henry Sucov, Frank Gilliland, and Scott Kanoski for winning the DORI’s first pilot proposal submission! Henry is from the Cell & Neurobiology Department and his proposal is entitled
Dr. Michael I. Goran teamed up with the Los Angeles County Department of Public Health to study the association between community-level economic hardship and childhood obesity prevalence in Los Angeles
Goran MI, Ulijaszek SJ, and Ventura EE. High fructose corn syrup and diabetes prevalence: A global perspective. Global Public Health. 2012; 1-10. The overall aim of this study was to
Goran MI, Walker R, Allayee H. Genetic-related and carbohydrate-related factors affecting liver fat accumulation. Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. Purpose of review To summarize recent findings
Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as
Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol. 2012 Jul 3. Gestational diabetes mellitus (GDM) carries a small but
Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits.
Bouret SG, Bates SH, Chen S, Myers MG, Simerly RB. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci. 2012 Jan 25; 32(4):1244-52.
A novel dual-color reporter for identifying insulin-producing beta-cells and classifying heterogeneity of insulinoma cell lines.
Lee NS, Rohan JG, Zitting M, Kamath S, Weitz A, Sipos A, Salvaterra PM, Hasegawa K, Pera M, Chow RH. A novel dual-color reporter for identifying insulin-producing Beta- cells and
Antony R, Sheng X, Ehsanipour EA, Ng E, Pramanik R, Klemm L, Ichihara B, Mittelman SD. Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. Leuk Res. 2012 May; 36(5):591-3.
Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function.
Caron E, Ciofi P, Prevot V, Bouret SG. Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci. 2012 Aug 15; 32(33):11486-94. It is increasingly
CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs.
Kim SP, Woolcott OO, Hsu IR, Stefanoski D, Harrison LN, Zheng D, Lottati M, Kolka C, Catalano KJ, Chiu JD, Kabir M, Ionut V, Bergman RN, Richey JM. CB1 antagonism
Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women.
Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. J Strength Cond Res. 2012 May; 26(5):1374-82.
Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling.
Moon BC, Hernandez-Ono A, Stiles B, Wu H, Ginsberg HN. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler
Stefanovski D, Youn JH, Rees M, Watanabe RM, Ader M, Ionut V, Jackson AU, Boehnke M, Collins FS, Bergman RN. Estimating hepatic glucokinase activity using a simple model of lactate
Dunton GF, Liao Y, Almanza E, Jerrett M, Spruijt-Metz D, Chou CP, Pentz MA. Joint physical activity and sedentary behavior in parent-child pairs. Med Sci Sports Exerc. 2012 Aug; 44(8):1473-80.