Research Highlights

Activation of Hindbrain Neurons Is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia

MaryAnn Bohland, Aleksey V. Matveyenko, Maziyar Saberi, Arshad M. Khan, Alan G. Watts, and Casey M. Donovan Hypoglycemic detection at the portal-mesenteric vein (PMV) appears mediated by spinal afferents and is critical for the counter-regulatory response (CRR) to slow-onset, but not rapid-onset, hypoglycemia. Since rapid-onset hypoglycemia induces Fos protein expression in discrete brain regions, we […]

The Rate of Fall of Blood Glucose Determines The Necessity of Forebrain-Projecting Catecholaminergic Neurons for Male Rat Sympathoadrenal Responses

Anne J. Jokiaho, Casey M. Donovan and Alan G. Watts Different onset rates of insulin-induced hypoglycemia use distinct glucosensors to activate sympathoadrenal counterregulatory responses (CCRs). Glucosensory elements in the portal-mesenteric veins are dispensable with faster rates when brain elements predominate, but are essential for responses to the slower onset hypoglycemia that is common with insulin […]

DORI’s First Annual Research Symposium – Feburary 19th

DORI’s First Annual Research Symposium From Cells to Psychology: Integrative Insights into Diabetes & Obesity Wednesday, February 19, 2014 from 8am to 5pm Keck School of Medicine of USC Norris Research Tower: Aresty Auditorium 1450 Biggy Street, Los Angeles, CA 90033   Featured Speakers: Carey Lumeng, MD, PhD – University of Michigan Medical School Christopher […]

Congratulations to the DORI’s first pilot proposal winners!

Congratulations to Henry Sucov, Frank Gilliland, and Scott Kanoski for winning the DORI’s first pilot proposal submission!  Henry is from the Cell & Neurobiology Department and his proposal is entitled “Molecular Biology and Physiology of Epicardial Adipose Tissue.”  Frank is from the Department of Preventive Medicine and his proposal is entitled “Environmental Obesogens, Breastfeeding and Early-Life […]

Community-level economic hardship and childhood obesity prevalence

Dr. Michael I. Goran teamed up with the Los Angeles County Department of Public Health to study the association between community-level economic hardship and childhood obesity prevalence in Los Angeles County, one of the largest and most ethnically diverse regions in the United States. Results are published in Pediatric Obesity. Shih M, Dumke KA, Goran MI, […]

High fructose corn syrup and diabetes prevalence: A global perspective

Goran MI, Ulijaszek SJ, and Ventura EE. High fructose corn syrup and diabetes prevalence: A global perspective. Global Public Health. 2012; 1-10. The overall aim of this study was to evaluate, from a global and ecological perspective, the relationships between availability of high fructose corn syrup (HFCS) and prevalence of type 2 diabetes. Using published resources, countrylevel estimates […]

Genetic-related and carbohydrate-related factors affecting liver fat accumulation

Goran MI, Walker R, Allayee H. Genetic-related and carbohydrate-related factors affecting liver fat accumulation. Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. Purpose of review To summarize recent findings that have examined dietary, genetic and gene–diet interactions that contribute to fat accumulation in the liver during growth and development, with particular focus on contributions […]

Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis.

Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia. 2012 Aug; 55(8):2183-92. Aims/Hypotheses We have previously documented a high heritability of insulin clearance in a […]

Gestational diabetes mellitus: risks and management during and after pregnancy.

Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol. 2012 Jul 3. Gestational diabetes mellitus (GDM) carries a small but potentially important risk of adverse perinatal outcomes and a long-term risk of obesity and glucose intolerance in offspring. Mothers with GDM have an excess of […]

Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits.

Bouret SG, Bates SH, Chen S, Myers MG, Simerly RB. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci. 2012 Jan 25; 32(4):1244-52. Circulating hormones influence multiple aspects of hypothalamic development and play a role in directing formation of neural circuits. Leptin is secreted by adipocytes and functions […]