Research Highlights

2015 DORI Seminar Calendar

Speaker Seminar Date University/Institute Jacob Friedman, PhD January 21 (Wed) University of Colorado School of Medicine 2nd Symposium Feb. 17 (Tue) & 18 (Wed) 10 speakers (8 external & 2 internal) Harvey Grill, PhD March 2 (Mon) University of Pennsylvania Wei Li, PhD March 10 (Tue) USC Ashlesha Datar, PhD April 14 (Tue) USC 4 […]

DORI 2015 Symposium Weblink

DORI’s symposium on Feb. 18th was recorded and can be viewed at the following link: http://keckmedia.usc.edu/Mediasite/Catalog/catalogs/dorisymposium

Congratulations to the DORI’s 2nd pilot proposal winners!

Congratulations to Fred Sattler, Steve Mittelman, and Ralf Langen & Pinchas Cohen for winning the DORI’s 2nd pilot proposal submission!  Fred is from the Department of Medicine and his proposal is entitled “PET/CT Scanning and PBMC Phenotyping to Non-invasively Identify and Quantify Deep Abdominal Fat Inflammation in Obesity: A target for pre-emptive therapy to prevent serious cardiometabolic […]

Activation of Hindbrain Neurons Is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia

MaryAnn Bohland, Aleksey V. Matveyenko, Maziyar Saberi, Arshad M. Khan, Alan G. Watts, and Casey M. Donovan Hypoglycemic detection at the portal-mesenteric vein (PMV) appears mediated by spinal afferents and is critical for the counter-regulatory response (CRR) to slow-onset, but not rapid-onset, hypoglycemia. Since rapid-onset hypoglycemia induces Fos protein expression in discrete brain regions, we […]

The Rate of Fall of Blood Glucose Determines The Necessity of Forebrain-Projecting Catecholaminergic Neurons for Male Rat Sympathoadrenal Responses

Anne J. Jokiaho, Casey M. Donovan and Alan G. Watts Different onset rates of insulin-induced hypoglycemia use distinct glucosensors to activate sympathoadrenal counterregulatory responses (CCRs). Glucosensory elements in the portal-mesenteric veins are dispensable with faster rates when brain elements predominate, but are essential for responses to the slower onset hypoglycemia that is common with insulin […]

DORI’s First Annual Research Symposium – Feburary 19th

DORI’s First Annual Research Symposium From Cells to Psychology: Integrative Insights into Diabetes & Obesity Wednesday, February 19, 2014 from 8am to 5pm Keck School of Medicine of USC Norris Research Tower: Aresty Auditorium 1450 Biggy Street, Los Angeles, CA 90033   Featured Speakers: Carey Lumeng, MD, PhD – University of Michigan Medical School Christopher […]

Congratulations to the DORI’s first pilot proposal winners!

Congratulations to Henry Sucov, Frank Gilliland, and Scott Kanoski for winning the DORI’s first pilot proposal submission!  Henry is from the Cell & Neurobiology Department and his proposal is entitled “Molecular Biology and Physiology of Epicardial Adipose Tissue.”  Frank is from the Department of Preventive Medicine and his proposal is entitled “Environmental Obesogens, Breastfeeding and Early-Life […]

Community-level economic hardship and childhood obesity prevalence

Dr. Michael I. Goran teamed up with the Los Angeles County Department of Public Health to study the association between community-level economic hardship and childhood obesity prevalence in Los Angeles County, one of the largest and most ethnically diverse regions in the United States. Results are published in Pediatric Obesity. Shih M, Dumke KA, Goran MI, […]

High fructose corn syrup and diabetes prevalence: A global perspective

Goran MI, Ulijaszek SJ, and Ventura EE. High fructose corn syrup and diabetes prevalence: A global perspective. Global Public Health. 2012; 1-10. The overall aim of this study was to evaluate, from a global and ecological perspective, the relationships between availability of high fructose corn syrup (HFCS) and prevalence of type 2 diabetes. Using published resources, countrylevel estimates […]

Genetic-related and carbohydrate-related factors affecting liver fat accumulation

Goran MI, Walker R, Allayee H. Genetic-related and carbohydrate-related factors affecting liver fat accumulation. Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. Purpose of review To summarize recent findings that have examined dietary, genetic and gene–diet interactions that contribute to fat accumulation in the liver during growth and development, with particular focus on contributions […]